MRSA and Amoebas

By now, most of us are familiar with MRSA or methicillin resistant Staphylococcus aureus. The staph bacteria is pretty common on human skin but doesn’t become a problem until it finds an entry through the flesh [afarensis had an old scar from a car accident get infected with staph, fortunately not MRSA, and spent about four days in the hospital last summer] at which point it becomes a problem. MRSA is mainly found in hospitals, although there have always been a number of cases where the person had never visited a hospital. Recent research may have uncovered why. According to Science Daily MRSA use amoeba to evade measures designed to halt their spread:

Scientists from the University of Bath have shown that MRSA infects and replicates in a species of amoeba, called Acanthamoeba polyphaga, which is ubiquitous in the environment and can be found on inanimate objects such as vases, sinks and walls.
As amoeba produce cysts to help them spread, this could mean that MRSA maybe able to be ‘blown in the wind’ between different locations.


This is where it gets really interesting. Apparently, by infecting the amoeba first the MRSA becomes more virulent:

Evidence with other pathogens suggests that pathogens that emerge from amoeba are more resistant to antibiotics and more virulent.
“This makes matters even more worrying,” said Professor Brown.
“It is almost as though the amoeba act like a gymnasium; helping MRSA get fitter and become more pathogenic.

In other words by they become more virulent by adapting to the amoeba defense system. There are evolutionary implications (and this study refutes the claims of those who say evolutionary theory does not contribute to the practice of modern medicine):

“In many ways this may reflect how this kind of pathogenic behaviour first evolved. A good example is the bacterium that causes legionnaires disease. Probably it was pathogenic long before humans and other animals arrived on the evolutionary scene. Even today, it has no known animal host.
“The most likely reason is that Legionella and many pathogens learned their pathogenicity after sparring with single-celled organisms like amoeba for millions of years. Because our human cells are very similar to these primitive, single-celled organisms, they have acquired the skills to attack us”.

As the researchers who performed the study point out effective control of MRSA requires a better understanding of it’s ecology including it’s interactions with other organisms. Which sounds like a promising are for future research…I’d almost give up writing about old bones and dirt for the opportunity to go back to school and study the issue…

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